Phosphorylation of golgin-160 by mixed lineage kinase 3

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Phosphorylation of golgin-160 by mixed lineage kinase 3.

Golgin-160 is a member of the coiled-coil family of golgin proteins, which are proposed to regulate the structure of the Golgi complex. The C-terminal two-thirds of golgin-160 is predicted to form a coiled-coil domain and the N-terminal head domain contains several putative binding domains, regulatory motifs and phosphorylation sites. Recently, it has been demonstrated that caspase-dependent cl...

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The weak inward rectifier potassium channel ROMK is important for water and salt reabsorption in the kidney. Here we identified Golgin-160 as a novel interacting partner of the ROMK channel. By using yeast two-hybrid assays and co-immunoprecipitations from transfected cells, we demonstrate that Golgin-160 associates with the ROMK C-terminus. Immunofluorescence microscopy confirmed that both pro...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2004

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.00897